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1

2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists

Dong-Mei Feng, Jenny M. Wai, Scott D. Kuduk, Christina Ng, Kathy L. Murphy, Richard W. Ransom, Duane Reiss, Raymond S.L. Chang, Charles M. Harrell, Tanya MacNeil, Cuyue Tang, Thomayant Prueksaritanont

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 112 KB

english, 2005

2

Bradykinin B1 antagonists: Biphenyl SAR studies in the cyclopropanecarboxamide series

Scott D. Kuduk, Robert M. DiPardo, Ronald K. Chang, Christina N. Di Marco, Kathy L. Murphy, Richard W. Ransom, Duane R. Reiss, Cuyue Tang, Thomayant Prueksaritanont, Douglas J. Pettibone, Mark G. Bock

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 148 KB

english, 2007

3

Cyclopropylamino Acid Amide as a Pharmacophoric Replacement for 2,3-Diaminopyridine. Application to the Design of Novel Bradykinin B 1 Receptor Antagonists

Wood, Michael R., Schirripa, Kathy M., Kim, June J., Wan, Bang-Lin, Murphy, Kathy L., Ransom, Richard W., Chang, Raymond S. L., Tang, Cuyue, Prueksaritanont, Thomayant, Detwiler, Theodore J., Hettrick

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 49 KB

english, 2006

4

Identification of S -( n -Butylcarbamoyl)glutathione, a Reactive Carbamoylating Metabolite of Tolbutamide in the Rat, and Evaluation of Its Inhibitory Effects on Glutathione Reductase in Vitro

Guan, Xiangming, Davis, Margaret R., Tang, Cuyue, Jochheim, Claudia M., Jin, Lixia, Baillie, Thomas A.

Journal:

Chemical Research in Toxicology

Année:

1999

Langue:

english

Fichier:

PDF, 173 KB

english, 1999

5

Drug-Drug Interactions Related to Altered Absorption and Plasma Protein Binding: Theoretical and Regulatory Considerations, and an Industry Perspective

Hochman, Jerome, Tang, Cuyue, Prueksaritanont, Thomayant

Journal:

Journal of Pharmaceutical Sciences

Année:

2015

Langue:

english

Fichier:

PDF, 164 KB

english, 2015

6

In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics

Tang, Cuyue, Shou, Magang, Rushmore, Thomas H., Mei, Qin, Sandhu, Punam, Woolf, Eric J., Rose, Mark J., Gelmann, Alyssa, Greenberg, Howard E., De Lepeleire, Inge, Van Hecken, Anne, De Schepper, Paul J

Journal:

Pharmacogenetics

Année:

2001

Langue:

english

Fichier:

PDF, 263 KB

english, 2001

7

Bradykinin B1 antagonists: SAR studies in the 2,3-diaminopyridine series

Scott D. Kuduk, Ronald K. Chang, Christina Ng, Kathy L. Murphy, Richard W. Ransom, Cuyue Tang, Thomayant Prueksaritanont, Roger M. Freidinger, Douglas J. Pettibone, Mark G. Bock

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 197 KB

english, 2005

8

5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists

Scott D. Kuduk, Christina Ng Di Marco, Ronald K. Chang, Michael R. Wood, June J. Kim, Kathy M. Schirripa, Kathy L. Murphy, Richard W. Ransom, Cuyue Tang, Maricel Torrent, Sookhee Ha, Thomayant Prueksa

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 301 KB

english, 2006

9

A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity

Dong-Mei Feng, Robert M. DiPardo, Jenny M. Wai, Ronald K. Chang, Christina N. Di Marco, Kathy L. Murphy, Richard W. Ransom, Duane R. Reiss, Cuyue Tang, Thomayant Prueksaritanont, Douglas J. Pettibone,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 154 KB

english, 2008

10

Bradykinin B1 receptor antagonists: An α-hydroxy amide with an improved metabolism profile

Scott D. Kuduk, Ronald K. Chang, Robert M. DiPardo, Christina N. Di Marco, Kathy L. Murphy, Richard W. Ransom, Duane R. Reiss, Cuyue Tang, Thomayant Prueksaritanont, Douglas J. Pettibone, Mark G. Bock

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 169 KB

english, 2008

11

Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists

Kelly-Ann S. Schlegel, Zhi-Qiang Yang, Thomas S. Reger, Youheng Shu, Rowena Cube, Kenneth E. Rittle, Phung Bondiskey, Mark G. Bock, George D. Hartman, Cuyue Tang, Jeanine Ballard, Yuhsin Kuo, Thomayan

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 615 KB

english, 2010

12

Indazole derivatives as novel bradykinin B1 receptor antagonists

Vera Bodmer-Narkevitch, Neville J. Anthony, Victoria Cofre, Samson M. Jolly, Kathy L. Murphy, Richard W. Ransom, Duane R. Reiss, Cuyue Tang, Thomayant Prueksaritanont, Douglas J. Pettibone, Mark G. Bo

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.32 MB

english, 2010

13

Pyridyl amides as potent inhibitors of T-type calcium channels

Thomas S. Reger, Zhi-Qiang Yang, Kelly-Ann S. Schlegel, Youheng Shu, Christa Mattern, Rowena Cube, Kenneth E. Rittle, Georgia B. McGaughey, George D. Hartman, Cuyue Tang, Jeanine Ballard, Yuhsin Kuo,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 870 KB

english, 2011

14

Simultaneous determination of urinary free cortisol and 6β-hydroxycortisol by liquid chromatography–atmospheric pressure chemical ionization tandem mass spectrometry and its application for estimating hepatic CYP3A induction

Cuyue Tang, Kelem Kassahun, Ian S McIntosh, Janice Brunner, A.David Rodrigues

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

2000

Langue:

english

Fichier:

PDF, 243 KB

english, 2000

15

Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations

Thomayant Prueksaritanont, Bennett Ma, Cuyue Tang, Yuan Meng, Carol Assang, Ping Lu, Paul J. Reider, Jiunn H. Lin, Thomas A. Baillie

Journal:

British Journal of Clinical Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 136 KB

english, 1999

16

Use ofIn VivoAnimal Models to Assess Pharmacokinetic Drug-Drug Interactions

Cuyue Tang, Thomayant Prueksaritanont

Journal:

Pharmaceutical Research

Année:

2010

Langue:

english

Fichier:

PDF, 304 KB

english, 2010

17

Theoretical Analysis of Interplay of Therapeutic Protein Drug and Circulating Soluble Target: Temporal Profiles of ‘Free’ and ‘Total’ Drug and Target

Cuyue Tang, Thomayant Prueksaritanont

Journal:

Pharmaceutical Research

Année:

2011

Langue:

english

Fichier:

PDF, 523 KB

english, 2011

18

Interactions of Human P-glycoprotein with Simvastatin, Simvastatin Acid, and Atorvastatin

Jerome H. Hochman, Nicole Pudvah, Julia Qiu, Masayo Yamazaki, Cuyue Tang, Jiunn H. Lin, Thomayant Prueksaritanont

Journal:

Pharmaceutical Research

Année:

2004

Langue:

english

Fichier:

PDF, 119 KB

english, 2004

19

Diclofenac hydroxylation in monkeys: Efficiency, regioselectivity, and response to inhibitors

Cuyue Tang, Yulin Fang, Catherine Booth-Genthe, Yuhsin Kuo, Scott D. Kuduk, Tom H. Rushmore, Brian A. Carr

Journal:

Biochemical Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 728 KB

english, 2007

20

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

Cuyue Tang, Yuhsin Kuo, Nicole T. Pudvah, Joan D. Ellis, Maria S. Michener, Melissa Egbertson, Samuel L. Graham, Jacquelynn J. Cook, Jerome H. Hochman, Thomayant Prueksaritanont

Journal:

Biochemical Pharmacology

Année:

2009

Langue:

english

Fichier:

PDF, 188 KB

english, 2009

21

P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes

Masato Chiba, Cuyue Tang, William E Neway, Theresa M Williams, S Jane Desolms, Christopher J Dinsmore, John S Wai, Jiunn H Lin

Journal:

Biochemical Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 171 KB

english, 2001

22

ADME of Biologics—What Have We Learned from Small Molecules?

Prueksaritanont, Thomayant, Tang, Cuyue

Journal:

The AAPS Journal

Année:

2012

Langue:

english

Fichier:

PDF, 366 KB

english, 2012

23

Design, Synthesis, and Evaluation of a Novel 4-Aminomethyl-4-fluoropiperidine as a T-Type Ca 2+ Channel Antagonist

Shipe, William D., Barrow, James C., Yang, Zhi-Qiang, Lindsley, Craig W., Yang, F. Vivien, Schlegel, Kelly-Ann S., Shu, Youheng, Rittle, Kenneth E., Bock, Mark G., Hartman, George D., Tang, Cuyue, Bal

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 209 KB

english, 2008

24

Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists

Barrow, James C., Rittle, Kenneth E., Reger, Thomas S., Yang, Zhi-Qiang, Bondiskey, Phung, McGaughey, Georgia B., Bock, Mark G., Hartman, George D., Tang, Cuyue, Ballard, Jeanine, Kuo, Yuhsin, Prueksa

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2010

25

A dynamic view to the modulation of phosphorylation and O-GlcNAcylation by inhibition of O-GlcNAcase

Tang, Cuyue, Welty, Devin F.

Journal:

Computational Biology and Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2013

26

Short-Acting T-Type Calcium Channel Antagonists Significantly Modify Sleep Architecture in Rodents

Yang, Zhi-Qiang, Schlegel, Kelly-Ann S., Shu, Youheng, Reger, Thomas S., Cube, Rowena, Mattern, Christa, Coleman, Paul J., Small, Jim, Hartman, George D., Ballard, Jeanine, Tang, Cuyue, Kuo, Yuhsin, P

Journal:

ACS Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.63 MB

english, 2010

27

Bioactivation of 2,3-Diaminopyridine-Containing Bradykinin B 1 Receptor Antagonists: Irreversible Binding to Liver Microsomal Proteins and Formation of Glutathione Conjugates

Tang, Cuyue, Subramanian, Raju, Kuo, Yuhsin, Krymgold, Sergey, Lu, Ping, Kuduk, Scott D., Ng, Christina, Feng, Dong-Mei, Elmore, Chad, Soli, Eric, Ho, Jonathan, Bock, Mark G., Baillie, Thomas A., Prue

Journal:

Chemical Research in Toxicology

Année:

2005

Langue:

english

Fichier:

PDF, 280 KB

english, 2005

28

Neuropharmacokinetics of two investigational compounds in rats: Divergent temporal profiles in the brain and cerebrospinal fluid

Tang, Cuyue, Chen, Ting, Kapadnis, Sudarshan, Hodgdon, Hilliary, Tao, Yi, Chen, Xing, Wen, Melody, Costa, Don, Murphy, Deirdre, Nolan, Scott, Flood, Dorothy G., Welty, Devin F., Koenig, Gerhard

Journal:

Biochemical Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2014

29

Prednisone has no effect on the pharmacokinetics of CYP3A4 metabolized drugs - midazolam and odanacatib

Marcantonio, Eugene E., Ballard, Jeanine, Gibson, Christopher R., Kassahun, Kelem, Palamanda, Jairam, Tang, Cuyue, Evers, Raymond, Liu, Chengcheng, Zajic, Stefan, Mahon, Chantal, Mostoller, Kate, Hren

Journal:

Journal of Clinical Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 286 KB

english, 2014

30

Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays

Stoiljkovic, Milan, Leventhal, Liza, Chen, Angela, Chen, Ting, Driscoll, Rachelle, Flood, Dorothy, Hodgdon, Hilliary, Hurst, Raymond, Nagy, David, Piser, Timothy, Tang, Cuyue, Townsend, Matthew, Tu, Z

Journal:

Biochemical Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 1.45 MB

english, 2015

31

Enzyme Kinetics of Cytochrome P450-Mediated Reactions

Shou, Magang, Lin, Yuh, Lu, Ping, Tang, Cuyue, Mei, Qin, Cui, Dan, Tang, Wei, Ngui, Jason, Lin, C., Singh, Rominder, Wong, Bradley, Yergey, James, Lin, Jiunn, Pearson, Paul, Baillie, Thomas, Rodrigues

Journal:

Current Drug Metabolism

Année:

2012

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2012

32

Intracellular Retention of Three Quinuclidine Derivatives in Caco-2 Permeation Experiments: Mechanisms and Impact on Estimating Permeability and Active Efflux Ratio

Jin, Hong, Kapadnis, Sudarshan, Chen, Ting, Lee, Dooyoung, McRiner, Andrew, Cook, Andrew, Burnett, Duane, Koenig, Gerhard, Tang, Cuyue

Journal:

Drug Metabolism Letters

Année:

2016

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2016

33

Discovery of MK-8719, A Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies

Selnick, Harold, Hess, J. Fred, Tang, Cuyue, Liu, Kun, Schachter, Joel, Ballard, Jeanine E., Marcus, Jacob Newman, Klein, Daniel J., Wang, Xiaohai, Pearson, Michelle, Savage, Mary J., Kaul, Ramesh, LI

Journal:

Journal of Medicinal Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2019